Composition
Each tablet contains Sertraline.
What is Zosert?
Zosert is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, panic disorder, obsessive-compulsive disorders (OCD), post-traumatic stress disorder (PTSD), and a severe form of premenstrual syndrome (premenstrual dysphoric disorder - PMDD). It may also be used to treat other conditions as determined by your doctor. Zosert works by helping to restore the balance of certain natural chemicals in the brain.
Zoloft is used to treat the symptoms of depression. It works by allowing nerves to communicate longer with each other through the presence of serotonin. It inhibits the reuptake of serotonin from the area between nerves (synapses).
Description
Zosert - Sertraline HCl is a selective serotonin reuptake inhibitor (SSRI) for oral administration. It is chemically unrelated to other SSRIs, tricyclic, tetracyclic, or other available antidepressant agents. It has a molecular weight of 342.7. Sertraline hydrochloride has the following chemical name: (1S-cis)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydro-N-methyl-1-nanphthalenamine hydrochloride. The empirical formula is C17H17NCl2·HCl.
Zoloft is supplied for oral administration as scored tablets containing sertraline hydrochloride equivalent to 25, 50 and 100 mg and the following inactive ingredients: dibasic calcium phosphate dihydrate, Dy & C Yellow #10 aluminum lake (in 25 mg tablet), FD & C Blue #1 aluminum lake (in 25 mg tablet), FD & C Red #40 aluminum lake (in 25 mg tablet), FD&C Blue #2 aluminum lake (in 50 mg tablet), hydroxypropyl cellulose, hydroxypropyl methylcellulose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, sodium starch glycolate, synthetic yellow iron oxide (in 100 mg tablet), and titanium dioxide.
Drug Interactions
The mechanism of action of sertraline is presumed to be linked to its inhibition of CNS neuronal uptake of serotonin (5HT). Studies at clinically relevant doses in man have demonstrated that sertraline blocks the uptake of serotonin into human platelets. In vitro studies in animals also suggest that sertraline is a potent and selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. In vitro studies have shown that sertraline has no significant affinity for adrenergic (alpha1, alpha2, beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5HT1A, 5HT1B, 5HT2), or benzodiazepine receptors; antagonism of such receptors has been hypothesized to be associated with various anticholinergic, sedative, and cardiovascular effects for other psychotropic drugs. The chronic administration of sertraline was found in animals to downregulate brain norepinephrine receptors, as has been observed with other clinically effective antidepressants. Sertraline does not inhibit monoamine oxidase.
Cautions
Several weeks may pass before Zosert reaches its full effect. Do not stop taking Zosert without checking with your doctor.
Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Zosert. Using Zosert alone, with other medicines, or with alcohol may lessen your ability to drive or to perform other potentially dangerous tasks.
Zosert will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
Before you begin taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes any medicines that contain dextromethorphan.
For Women
If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using Zosert during pregnancy.
It is unknown IF Zosert is excreted in breast milk. If you are or will be breast-feeding while you are using Zosert, check with your doctor or pharmacist to discuss the risks to your baby.
Side Effects
Some people taking Zoloft may have side effects.
The most common side effects reported include
In clinical studies with Zoloft, few patients were bothered enough by side effects to stop taking their medicine. Tell your doctor about any side effects you may be experiencing. Your doctor may be able to adjust your treatment plan to help you feel better.
If overdose is suspected, contact your local poison control center or emergency room immediately. Symptoms of overdose may include: irregular heartbeat, fainting, severe dizziness or lightheadedness.
